Journal article
Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: A prospective nested case-control study
PA Dugué, MT Brinkman, RL Milne, EM Wong, LM FitzGerald, JK Bassett, JE Joo, CH Jung, E Makalic, DF Schmidt, DJ Park, J Chung, AD Ta, DM Bolton, A Lonie, A Longano, JL Hopper, G Severi, R Saffery, DR English Show all
British Journal of Cancer | SPRINGERNATURE | Published : 2016
DOI: 10.1038/bjc.2016.237
Abstract
Background: Global DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk. Methods: We used 439 case-control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confoun..
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Awarded by National Science Foundation
Funding Acknowledgements
This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We also express our gratitude to the many thousands of Melbourne residents who took part in the study and provided blood samples. This work was supported by the National Health and Medical Research Council project grant number 1043616.